Sebia Explores the Limitations and Benefits of Immunofixation and Immunotyping

Daniel L. Hood, MD Medical Director, CompuNet Clinical Labs and Miami Valley Hospital

Monoclonal Gammopathies (MG) are characterized by chromosomal aberration of B-cells or plasma cells resulting in benign or malignant proliferation of the affected clone. The product of such clone, a monoclonal protein, is an essential laboratory marker for the detection, identification and classification of MG and aid in diagnosing the associated conditions.

Currently there is no one test sensitive and specific enough to detect all Monoclonal Gammopathies. In some cases, multiple tests, including serum free light chain analysis, are required to uncover all plasma cell dyscrasias present in the patient.

Two electrophoresis techniques commonly used in clinical laboratory for typing MGs are Immunofixation and Immunotyping. During Immunofixation, samples are separated on a gel using zone electrophoresis and separation products are overlaid with specific antisera for detection. On capillary systems, MG can be characterized by mixing sample with Ig-specific antibodies followed by separation in an electrical field and observing resulting patterns for specific reduction of monoclonal peaks.

In this webinar, which is sponsored by Sebia, the speaker will discuss strategies for detecting Monoclonal Gammopathies. Participants will learn the principles of Immunotyping and Immunofixation, as well as review Immunotyping and Immunofixation results.

Dr. Daniel L. Hood, the Medical Director at CompuNet Clinical Labs and Miami Valley Hospital, will be the speaker for this event.

Hood attended The Ohio State University and received a Bachelor of Science in microbiology and immunology before graduating from Wright State University School of Medicine with his doctorate. Since 1997, he has been medical director of the clinical labs at Miami Valley Hospital and the CCL lab. During his career he has been on the boards of Miami Valley Hospital, Premier Health hospital system, Community Blood Center/Community Tissue Services, Ohio Society of Pathologists, and The Joint Restoration Foundation as well as serving as system pathology chair for Premier Health hospital system.

LabRoots will host the webinar December 5, 2017, beginning at 10:00 a.m. PST, 1:00 p.m….

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