“The findings of this proposal will not only help patients suffering from the evoked nausea and vomiting, but will also introduce several new classes of broad-spectrum antiemetics, which will lower the cost of prevention of nausea and vomiting in diverse patient communities.”
Pomona, Calif. (PRWEB)
September 25, 2017
Nissar A. Darmani, PhD, has been awarded a record WesternU research grant of more than $1.5 million to help cancer patients suffering from chemotherapy-evoked nausea and vomiting. Dr. Darmani is Associate Dean of Basic Medical Sciences in the College of Osteopathic Medicine of the Pacific (COMP).
The five-year grant is from the National Cancer Institute (NCI) arm of the National Institutes of Health (NIH). It is to investigate vomiting signals and crosstalk within brainstem and gut nerves as well as cells responsible for delayed-phase vomiting in the course of cancer chemotherapy with cis-platinum.
“The findings of this proposal will not only help patients suffering from the evoked nausea and vomiting, but will also introduce several new classes of broad-spectrum antiemetics, which will lower the cost of prevention of nausea and vomiting in diverse patient communities suffering from cancer, HIV or gastrointestinal disorders,” Darmani said.
Cancer is the second-leading cause of death globally and was responsible for 8.8 million deaths in 2015. The total annual economic cost of cancer worldwide in 2010 was $1.16 trillion, according to the World Health Organization.
Expenses associated with the prevention of the first and delayed phases of chemotherapy-induced nausea and vomiting (CINV) are costly, especially inpatient hospitalizations. Strategies to reduce CINV can help to reduce health care utilization and costs, according to Burke, T.A., Wisniewski, T. & Ernst, F.R. Support Care Cancer (2011) 19: 131. https://doi.org/10.1007/s00520-009-0797-x
“This is wonderful news. Not only has Dr. Darmani been awarded a major NIH grant, but his work may will bring a long-sought remedy for the stubbornly awful syndromes of nausea, particularly as often afflict cancer…