Multivitamins May Reduce Incidence of Neuropathy from Chemotherapy, Shows New Study

Christine Ambrosone, PhD, Roswell Park Alliance Foundation Endowed Chair in Cancer Prevention at Roswell Park Cancer Institute

Chemotherapy-induced peripheral neuropathy, or CIPN, is a common side effect of cancer treatment that causes shooting or burning pain, numbness, tingling and cold sensitivity of the hands and feet for many cancer patients. A new study from Roswell Park Cancer Institute found that women who took multivitamin supplements before their breast cancer diagnosis and/or during treatment, however, were less likely to develop these debilitating and often long-lasting symptoms. The study was published online ahead of print in the Journal of the National Cancer Institute (JNCI).

An estimated 30% to 40% of cancer patients who receive chemotherapy experience CIPN, enduring pain that diminishes sleep and quality of life and can make everyday activities such as walking or buttoning a shirt difficult. CIPN commonly leads to dose reduction or discontinuation of chemotherapy. Symptoms can persist after treatment ends and become permanent. Some chemotherapy drugs, such as taxanes and platinum-based compounds, are more likely than others to cause it. Currently, no known preventive intervention for the side effect exists.

“Our study showed that use of multivitamin supplements, but not specific vitamins, was associated with less neurotoxicity,” says Roswell Park researcher and the study’s senior author, Christine Ambrosone, PhD, Senior Vice President for Population Sciences and Roswell Park Alliance Foundation Endowed Chair in Cancer Prevention. “This was true for use before diagnosis and, to a lesser extent, during chemotherapy.”

“Symptoms of CIPN often persist after completion of chemotherapy, and effective treatment options are limited,” notes the paper’s first author, Gary Zirpoli, PhD, a graduate of Roswell Park’s doctoral program in cancer prevention who is now a research fellow with the Department of Neurology at Massachusetts General Hospital and Harvard Medical School. “Identifying preventive measures is therefore a critical part of enhancing quality of life for breast cancer survivors.”

Some studies have evaluated the use of dietary supplements in relation to breast cancer prognosis, but…

Read the full article from the Source…

Leave a Reply

Your email address will not be published. Required fields are marked *