Genes linked to homosexuality have been discovered by scientists in the biggest ever study into the genetic basis for sexual orientation.
For the first time, researchers looked at the complete genome – a person’s entire DNA code – for more than 1,000 gay men and compared it to genetic data from a similar number of heterosexual males.
They discovered that DNA was different for gay and straight men around the genes SLITRK5 and SLITRK6.
SLITRK6 is an important gene for brain development, and is particularly active in a region of the brain which includes the hypothalamus.
The hypothalamus is crucial for producing the hormones which control sex drive, and previous studies have shown parts of it are up to 34 per cent larger in gay men.
The researchers, from North Shore University Health System’s Research Institute, in Illinois, US, also discovered differences in the TSHR gene, which is linked to the thyroid, another area which has previously been associated with sexual orientation.
“Because sexuality is an essential part of human life – for individuals and society – it is important to understand the development and expression of human sexual orientation,” said lead author Dr Alan Sanders.
“The goal of this study was to search for genetic underpinnings of male sexual orientation, and thus ultimately increase our knowledge of biological mechanisms underlying sexual orientation.
“What we have accomplished is a first step for genome wide study on the trait, and we hope that subsequent larger studies will further illuminate its genetic contributions.”
Participants in the study were rated for sexual orientation based on their self-reported sexual identity and sexual feelings.
Men were asked to provide DNA by blood or saliva samples that were then genotyped and analysed.
Although previous studies have pointed to a genetic predisposition for homosexuality, it is the first time researchers have studied the entire genome of individuals and so is the most comprehensive assessment of the genetic basis of sexuality ever undertaken.
However British experts said more work was needed before it was possible to identify ‘gay genes’ because the genetic differences could point to other traits shared by the homosexual respondents.
For example the variations may simply predispose people to be more open or candid about their lives.