Police raced to Stockwell Road, between Stockwell and Brixton tube stations, at around 3am this morning after reports of a dramatic collision.
Images from the scene show debris scattered across the road as the flashing blue lights from police and ambulances lit up houses and buildings.
Five male pedestrians – aged between 23 and 42 years – were taken to hospital by ambulance.
Kevin Bate, deputy director of Operations at London Ambulance Service, said six ambulance crews, two advance paramedics, two incident response officers, a hazardous area response team and air ambulance medics attended.
He said: “We treated five patients on the scene for a range of head and leg injuries. We took one patient as a priority to a major trauma centre and took four patients as a priority to a trauma centre.”
Police initially reported that two people were a “critically injured”, but a spokesman later confirmed none of the five are in a critical condition.
The Metropolitan Police say the incident which happened this morning is not being treated as terrorism.
Officers believe the collision occurred shortly after an “altercation” between the occupants of the vehicle and a number of pedestrians.
The car, a VW Golf, was abandoned at the scene. A number of occupants made off on foot.
A Metropolitan Police spokesman said: “Detectives from Lambeth CID are investigating.
“Officers believe the incident occurred shortly after an altercation between the occupants of the vehicle and a number of people in Stockwell Road.
“This is not a terrorist incident, and is not being treated as a hate crime.
“At this very early stage, there has been no arrest. Enquires continue to establish the circumstances.”
The road has been closed off as police investigate the collision, and buses are following diverted routes.
Transport for London say Stockwell Road is closed both ways between Sidney Roadd and Stockwell Park Walk following “an overnight police incident & ongoing investigation”.
In a tweet, they said: “Traffic is currently flowing well locally on diversion in the area though delays may occur later.”
The road closure is expected to go on all morning, but according to Twitter user Stephen Canning “local residents are helping people navigate the estates on foot”.
Anyone who witnessed the incident, or the events before or after the collision, is urged to call officers from Lambeth CID on 101. You can tweet officers @MetCC.
To remain anonymous call Crimestoppers on 0800 555 111…